HORDB

ID: hor006563
Uniprot ID: P87352
Protein name: Corticotropin-like intermediary peptide
Gene name: pomc
Organism: Acipenser transmontanus (White sturgeon)
Family: POMC family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Acipenser (genus), Acipenserini (tribe), Acipenserinae (subfamily), Acipenseridae (family), Acipenseroidei (suborder), Acipenseriformes (order), Chondrostei (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: PVKVYPNGVEEESAESYPAEIRRDLSLKLDYPQGEELEEVFGGENDLLNLQ
Length: 51(158-208)
Propeptide: MLHPVWGCVVAVMGVLWFYSSGVQSQCWEHSQCRDLASEANILECIQACKVDLSAESPLFPGNGHLQPTSEDIQNYVMSHFHWNTFGQRMNGTPGGSKREGASTALSVLLEALSQPRDEVERESEEEEGLQQHRRDDKRSYSMEHFRWGKPVGRKRRPVKVYPNGVEEESAESYPAEIRRDLSLKLDYPQGEELEEVFGGENDLLNLQKKDGSYKMNHFRWSGPPKDKRYGGFMKSWDERSQKPLLTLFKNVMIK
Signal peptide: MLHPVWGCVVAVMGVLWFYSSGVQS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: [Corticotropin]: Stimulates the adrenal glands to release cortisol.; [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; [Melanocyte-stimulating hormone beta]:
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006563_AF2.pdb

hor006563_ESM.pdb

Mass:	667232	Formula:	C255H394N64O89
Absent amino acids:	CHMTW	Common amino acids:	E
pI:	3.76	Basic residues:	4
Polar residues:	13	Hydrophobic residues:	15
Hydrophobicity:	-78.04	Boman Index:	-11094
Half-Life:	>20 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	?	Aliphatic Index	87.84
Instability Index:	7239.22	Extinction Coefficient cystines:	4470
Absorbance 280nm:	89.4